After revolutionizing the management of hepatitis C, DAAs (Directly Acting Antivirals) are all set to expand the donor pool in deceased donor kidney transplantation.
In an RCT from Kolkata, Basu et al randomized 176 children aged 3 to 16 years with the corticosteroid-dependent nephrotic syndrome to receive either tacrolimus (along with tapering alternate-day prednisolone) for 12 months or a single course of rituximab (2 infusions of 375mg/m2).
In a primary cohort of 666 children and a validation cohort comprising of 333 children who underwent cardiac surgery with cardiopulmonary bypass, the incidence of AKI was higher among those with no acetaminophen exposure than among those with acetaminophen exposure.
“Among women with uncomplicated UTI, a 5-day course of nitrofurantoin compared with single-dose fosfomycin resulted in a significantly greater likelihood of clinical and microbiologic resolution at 28 days after therapy completion”
On the occasion of World Kidney Day, MNG in collaboration with IMA arrranged CME in 3 locations. Over 700 GPs attended the program. The program involved each and every MNG member.
In their monthly blog “last month in Nephrology” Dr. Tukaram Jamale and Dr. Vaibhav Keskar try to think aloud on the published evidence, and no way claim to be the final word which probably doesn’t exist in science.
As we all know, the quest for knowledge is an eternal process. And this thought is something that has been inscribed deeply into our minds at the Mumbai Nephrology Group (MNG).We are always in a process of reinventing ourselves to continue to learn and spread the knowledge.
If you initiate dialysis a few hours earlier in the course of AKI-that essentially means dialyzing almost every AKI that needs nephro consult–you get almost everything that you will like to offer your critically ill patient with AKI: 15.4% absolute risk reduction in mortality.
Half of the globe was fast asleep then [when it was 3:15pm (PST) on 13th November at Anaheim, California]. I had just completed reading Murakami’s ‘Samsa in love’.
In this Cochrane review of 11 RCTs involving 29141 diabetics, intensive control of sugars (HbA1c < 7% or FBS <120) made little or no difference in the renal and patient survival endpoints: doubling of serum creatinine, ESRD or death as compared to the usual control (HbA1c >7 or FBS >120).
A secondary analysis of SPRINT trial (BTW, how many can be done per trial?), looking at the Effects of Intensive Systolic Blood Pressure Control on Kidney and Cardiovascular Outcomes in Persons Without Kidney Disease is published in Annals of Internal Medicine.
TESTING was a multicenter, double-blind, randomized clinical trial which planned to enroll 750 participants with IgA nephropathy (proteinuria greater than 1 g/d and estimated glomerular filtration rate [eGFR] of 20 to 120 mL/min/1.73 m2) after at least 3 months of blood pressure control with renin-angiotensin system blockade.
Urinary creatinine clearance 59 ml/min, DTPA GFR 75 ml (gates), 65 ml (plasma sampling), CKD-EPI 90 ml/min, CKD-EPI using cystatin C 102 ml/min–these are ‘GFR’ values by various methods for one of our perfectly healthy 58-year-old donor under evaluation.
RCT in Nephrology is that rare occasion to celebrate especially if it is positive. Here is a multi-centre, double-blind, placebo-controlled trial (NEFIGAN) of Targeted-release formulation ((TRF) budesonide versus placebo in patients with IgA nephropathy.
April – May 2017
In this JASN study, 105 pregnancies classified as rAKI (pregnant women with history of recovered AKI) were compared with 24640 control pregnancies-authors noted that “past episode of AKI, despite return to normal renal function before pregnancy, associated with maternal adverse outcomes in pregnancy”.